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Biomedical Centre, BMC, May 2022

Yasmin Binti Shamsudin

Principal Investigator

Yasmin got her MSc. Chemical Engineering and PhD in Molecular Biotechnology  from Uppsala University, Sweden. She then went to Stanford University, USA, as a Wallenberg postdoctoral research fellow, before returning to Uppsala University as faculty.

Yasmin’s research focuses on understanding the dynamics of proteins and the molecular mechanisms of binding, inhibition and catalysis of small molecules in enzymes. She is also interested in protein and enzyme engineering and engages in computational methods development.

Current Members

Alexandros Zantis

I am Alexandros Zantis, currently working on my master thesis in Yasmin Binti Shamsudin Lab.

In this project I model metallo-β-lactamases(MBLs) with inhibitors. In particular, the focus is on L1 from B3 class and VIM-2 from B1 class. The inhibitors to be investigated are Indole-2-carboxylates(InCs). The inhibitor choice is based on the inhibition activity they have towards the selected targets. Therefore, inhibitors that show different activities with the targets are chosen to aid comparison.

This project aims to computationally unravel structural features of the targets and accordingly which molecular interactions with InCs are responsible for higher inhibition activities.

Marco Halbeisen

I’m a master student investigating the projected field by the beta lactamase OXA-48 onto the carbonyl group of four different DBO-scaffold inhibitors (Avibactam, ETX, ETX-F, Relebactam) and the antibiotic substrate imipenem.

My main interests are structural biology, protein chemistry and drug design both experimentally and computationally.

Federica Serlini

Federica models beta-lactamase with inhibitors.

More information about her project will be posted soon.


Isabell Lindahl

MSc Degree project | Jan 2022 - June 2022

IMI-1, Class A β-lactamase, carbapenamase, carbapenem antibiotics


Linda Liljeholm

MSc Degree project | Jan 2022 - June 2022

OXA-48, Class D β-lactamase, carbapenamase, DBO inhibitors, Avibactam


Alexander Lidén

MSc Degree project | Jan 2022 - June 2022

TEM 1, Class A β-lactamase mutants, Penicillin G, β-lactamase inhibitors, Avibactam

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