In this paper, we use computational methods to guide the design of GFP that can be cleaved and photodissociated. The simulations resulted in three suggested mutation sites, with up to 20 times faster photodissociation for the triple-alanine mutant. The article is available for free here.
New Nature Communications paper on protein engineering of GFP Read More »
We welcome Federica Serlini, an ERASMUS student from the University of Padua, Italy, to the group. Federica will be modelling and simulating beta-lactamases, antibiotics, and inhibitors during her 6-month research internship with us. More information about Federica’s project can be found on the People page.
We welcome Alexandros Zantis and Marco Halbeisen to the group. Both are students at the MSc in Chemistry program at Uppsala University, and will work on modelling beta-lactamases using computational methods. More information about their projects is found in the “People” page.
Our latest JACS paper titled “Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of β-Lactamases” has been highlighted in Derek Lowe’s Science blog “In the Pipeline”: https://www.science.org/content/blog-post/electric-fields-make-enzyme
Paper highlighted in Science blog Read More »
The paper, titled “Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of β-Lactamases” describes how changes in electric fields projected on the reacting bond on the ligand correlates with catalytic rates and activity in TEM-1 β-Lactamase. Read more here: https://doi.org/10.1021/jacs.2c09876
New JACS paper on Electric Fields in β-Lactamases Read More »
For successfully defending her degree project today! Isabell’s thesis is about the Class A beta-lactamase IMI-1. She has simulated the enzyme with and without antibiotics to understand the dynamics and binding mechanisms. Well done drawing the audience in and keeping them engaged throughout the presentation! A link to Isabell’s thesis can be found in the
Congratulations to Isabell Read More »
For successfully defending her degree project today! Well done parrying the deluge of questions from the opponents(!), subject specialist, and examiner!
Congratulations to Linda Read More »
For successfully defending his degree project today! A great presentation, interesting discussion and valuable results!
Congratulations to Alex Read More »
Welcome to our three new group members, Alexander Lidén, Isabell Lindahl, and Linda Liljeholm! They are final year Masters degree students in Chemical Engineering at Uppsala University, finishing their program with a computational degree project in our lab. More information about them and their projects will soon be available in the People page.
I’ve started my position as a Researcher at the Department of Chemistry – BMC funded by the Knut and Alice Wallenberg Foundation. I will be working in the fields of computational enzymology and protein engineering. However, my main project is methods development of a purely computational approach to accurately estimating electric fields in biomolecules. The